Springer Series in Statistics Multiple Testing Procedures with Applications to Genomics

Type

Book

Authors

Dudoit ( Dudoit, Sandrine )

van der Laan ( van der Laan, Mark J. )

ISBN 10

0387493166

ISBN 13

9780387493169

Tags

Computers & Technology, Anatomy, Bioinformatics, Biostatistics, Genetics, Probability & Statistics, Computer Science, Reference, Anatomy & Physiology, Statistics

Series Name

Springer Series in Statistics

Description

This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics. - from Amzon

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